Soluble micro-granules for preparation

as an injectable solution

COMPOSITION

2.36 g sachet:

Diminazene diaceturate 1.05 g

Cyanocobalamin (Vitamin B12) 0.6 mg

Hydroxocobalamin (Vitamin B12a) 2.4 mg

Excipient (Antipyrine)……. (qsf) 1 sachet (2.36 g)

23.6 g sachet:

Diminazene diaceturate 10.5 g

Cyanocobalamin (Vitamin B12) 6.0 mg

Hydroxocobalamin (Vitamin B12a) 24.0 mg

Excipient (Antipyrine)……. (qsf) 1 sachet (23.6 g)

PROPERTIES

The active ingredient of VERIBEN B12 Long-acting is diminazene, a drug of the

diamidines family used as an aceturate salt. Diminazene is highly active against

both Trypanosoma and Babesia spp.

VERIBEN B12 Long acting contains cyanocobalamin (vitamin B12) and

hydroxocobalamin (Vitamin B12a) a long acting analogue of cyanocobalamin.

Injection of hydroxocobalamin gives sustained high blood levels of vitamin B12.

Vitamin B12 is necessary for the synthesis of red blood cells and growth.

The anaemia observed during trypanosomiasis is caused by a rumen stasis

which reduces the synthesis of vitamin B12.

Concurrent long acting vitamin B12 administration, therefore allows a quicker

recovery of haematocrits.

The antipyrine, included in the excipient, ensures a complete solubility of the

active ingredient and helps to aleviate inflammation and fever.

INDICATIONS

Cattle, sheep and goats:

Treatment of protozoal diseases:

- Trypanosomosis due to Trypanosoma congolense, T. vivax et T. brucei.

- Piroplasmosis due to Babesia bovis, B. bigemina, B. ovis, B. motasi.

ADMINISTRATION AND DOSAGE

Deep intramuscular route.

The recommended dose is 3.5 mg of diminazene diaceturate per kg bodyweight in a single

injection. Do not exceed a total dose of 4 g of active ingredient in any animal.

Cattle, sheep and goats: Prepare the injectable solution by adding 15 ml of sterile water

to each 2.36 g sachet. For the 23.6 g sachet it is necessary to add 150 ml of sterile water.

Thoroughly mix the water and granules before injecting the prepared solution according

to the following table:

One injection is sufficient for each treatment.

NB : In case of T. brucei infestation, the above dosage recommendations should be doubled.

Where resitants agents are a problem, dosage rates can be increased to as high as 13.18 ml

of the reconstituted solution for 100 kg body weight (as 8 mg diminazene diaceturate per

kg b.w.) but without injecting more than 65.7 ml per animal (4 g diminazene diaceturate/

animal).

PRECAUTIONS

In case a of a large volume needs to be injected, it is recommended to divide the dose

between two separate sites. Inject animals strictly according to body mass.

Keep out of reach of children.

WITHDRAWAL PERIODS

Meat and offals: 21 days.

STORAGE

Sealed sachets can be stored in a cool dry place below 30°C.

The reconstituted solution can be stored for up to 7 days in a fridge, protected from light

and in a closed glass bottle.

PRESENTATIONS

Box with 10 x 2.36 g sachets.

Box with 10 x 23.6 g sachets.